This 52 page tutorial was developed by Research Advocacy Network to assist research advocates in developing strategies and contributing to discussions about clinical trial design. Text includes an expanded glossary of terms, discussion of Bayesian statistical design. AVAILABLE ONLY IN PDF FORMAT. Authored by Jane Perlmutter, PhD and funded by the Advocacy Core of Indiana University Breast Cancer Center of Excellence for Individualization of Therapy (George Sledge, MD, Principal Investigator).